Program

Location

Edwards Hall Lobby

Document Type

Poster Presentation (1 hour)

Description

Inosoxy Catalyzed Aliphatic Nitro-Compound Electroreduction Nitroalkanes are widely being used for many purposes like industrial solvents, fuel in racing cars or rockets, chemical intermediates and also in explosives like TNT and Nitroglycerine. These compounds when released into the environment and inhaled by human beings cause headaches, nausea, convulsions, neuropathy and can irreversibly damage the DNA double helix acting as carcinogens. The activation of these xenobiotic nitro compounds by inosoxy enzyme (a p450 like enzyme) can be a potent explanation for the nitro compound related health issues. However, a detailed explanation of the mechanism is still not known. The formation of nitrosoalkane-heme complex can be a possible explanation for the mechanism of activation of the aliphatic nitro-compound xenobiotic. The study shows that the oxygenase domain of inducible nitric oxide synthase (iNOSoxy) acts as an efficient electrocatalyst for nitroalkane reductions in the surfactant films on pyrolytic graphite electrodes. The electrocatalytic process used was cyclic voltammetry and three aliphatic Nitro alkanes like Nitromethane, Nitroethane and Nitropropane were used for the study. By comparing the electro-reduction of each Nitroalkane substrate at different concentrations and by varying experimental conditions such as scan rate of cyclic voltammetry we discussed the effects caused by the substrates on their electrocatalytic reductions. Graphic and simulation software Origin® was utilized to quantitatively derive parameters from experimental raw data.

Start Date

20-4-2013 10:30 AM

Comments

Math, Sciences and Engineering Poster Session

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Apr 20th, 10:30 AM

Inosoxy Catalyzed Aliphatic Nitro-Compound Electroreduction

Edwards Hall Lobby

Inosoxy Catalyzed Aliphatic Nitro-Compound Electroreduction Nitroalkanes are widely being used for many purposes like industrial solvents, fuel in racing cars or rockets, chemical intermediates and also in explosives like TNT and Nitroglycerine. These compounds when released into the environment and inhaled by human beings cause headaches, nausea, convulsions, neuropathy and can irreversibly damage the DNA double helix acting as carcinogens. The activation of these xenobiotic nitro compounds by inosoxy enzyme (a p450 like enzyme) can be a potent explanation for the nitro compound related health issues. However, a detailed explanation of the mechanism is still not known. The formation of nitrosoalkane-heme complex can be a possible explanation for the mechanism of activation of the aliphatic nitro-compound xenobiotic. The study shows that the oxygenase domain of inducible nitric oxide synthase (iNOSoxy) acts as an efficient electrocatalyst for nitroalkane reductions in the surfactant films on pyrolytic graphite electrodes. The electrocatalytic process used was cyclic voltammetry and three aliphatic Nitro alkanes like Nitromethane, Nitroethane and Nitropropane were used for the study. By comparing the electro-reduction of each Nitroalkane substrate at different concentrations and by varying experimental conditions such as scan rate of cyclic voltammetry we discussed the effects caused by the substrates on their electrocatalytic reductions. Graphic and simulation software Origin® was utilized to quantitatively derive parameters from experimental raw data.