Presenter Information

Amanda Shaw, SUNY CortlandFollow

Academic Field

Psychology

Faculty Mentor Name

Joshua Peck

Presentation Type

Oral Presentation

Abstract

Perineuronal Nets (PNNs) are specialized extracellular matrix structures of the brain that are found around specific neurons. PNNs play a role in structural and developmental plasticity, it remains unknown how they are affected by drugs of addiction. In the US, drug use has a very profound impact medically, economically, and socially. We used a conflict model which mimicked human drug seeking behaviors. Abstinence of heroin seeking was achieved by placing an electric barrier between the animal and drug access and increasing the shock intensities. Relapse was induced by non-contingent presentations of a drug cue. We conducted an analysis on PNN density using Wisteria Floribunda Agglutinin, We found that there was a strong negative correlation between PNN density and heroin infusion volumes during the drug acquisition phase. These findings suggest that PNNs are affected by heroin self-administration and may play a role in regulating plasticity within the brains of drug abusers.

Keywords

perineuronal nets, extracellular matrix, neural plasticity, drug addiction, heroin, relapse

Start Date

10-4-2015 4:15 PM

End Date

10-4-2015 5:30 PM

Location

Hartwell Hall 217

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Apr 10th, 4:15 PM Apr 10th, 5:30 PM

The Effect of Heroin Self-Administration on Perineuronal Nets using an Animal Conflict Model of Abstinence and Relapse

Hartwell Hall 217

Perineuronal Nets (PNNs) are specialized extracellular matrix structures of the brain that are found around specific neurons. PNNs play a role in structural and developmental plasticity, it remains unknown how they are affected by drugs of addiction. In the US, drug use has a very profound impact medically, economically, and socially. We used a conflict model which mimicked human drug seeking behaviors. Abstinence of heroin seeking was achieved by placing an electric barrier between the animal and drug access and increasing the shock intensities. Relapse was induced by non-contingent presentations of a drug cue. We conducted an analysis on PNN density using Wisteria Floribunda Agglutinin, We found that there was a strong negative correlation between PNN density and heroin infusion volumes during the drug acquisition phase. These findings suggest that PNNs are affected by heroin self-administration and may play a role in regulating plasticity within the brains of drug abusers.