Academic Field

Biological Sciences

Faculty Mentor Name

Bernardo Ortega

Presentation Type

Oral Presentation

Abstract

Magnesium (Mg2+) is the second most abundant ion in the body but its regulation is poorly understood. Mg2+ deficiency is known to interfere with the physiological regulation of other electrolytes, such as calcium (Ca2+) and phosphate (Pi), and a number of hormones have been implicated in mediating such disturbances. Here we use a mouse model to understand how these changes occur over time. We show that in as little as one day, mice experienced a dramatic decrease in Mg2+ and Ca2+ excretion in urine. At the same time, Pi excretion was significantly increased. Given the speed of these changes, it is unlikely that FGF-23 regulates the increase in Pi excretion. Instead, other factors such as PTH may have a predominant role during the early stages of hypomagnesaemia. Our ultimate goal is to unravel the precise mechanism by which Mg2+ deficiency affects the regulation of Ca2+ and Pi, and understand the involvement of hormones such as PTH, FGF-23 and vitamin D in mediating these changes.

Keywords

Magnesium, magnesium deficiency, Phosphate excretion, Calcium excretion, FGF23, PTH

Start Date

10-4-2015 4:15 PM

End Date

10-4-2015 5:30 PM

Location

Hartwell Hall 122

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Apr 10th, 4:15 PM Apr 10th, 5:30 PM

Development of Hypocalciuria and hyperphosphaturia during early stages of magnesium deprivation in mice

Hartwell Hall 122

Magnesium (Mg2+) is the second most abundant ion in the body but its regulation is poorly understood. Mg2+ deficiency is known to interfere with the physiological regulation of other electrolytes, such as calcium (Ca2+) and phosphate (Pi), and a number of hormones have been implicated in mediating such disturbances. Here we use a mouse model to understand how these changes occur over time. We show that in as little as one day, mice experienced a dramatic decrease in Mg2+ and Ca2+ excretion in urine. At the same time, Pi excretion was significantly increased. Given the speed of these changes, it is unlikely that FGF-23 regulates the increase in Pi excretion. Instead, other factors such as PTH may have a predominant role during the early stages of hypomagnesaemia. Our ultimate goal is to unravel the precise mechanism by which Mg2+ deficiency affects the regulation of Ca2+ and Pi, and understand the involvement of hormones such as PTH, FGF-23 and vitamin D in mediating these changes.